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ACROBiosystems Human GITR Ligand / TNFSF18 Protein, Fc Tag
Marke: ACROBiosystems GIL-H526A-50UG
Weitere Details : Netto-Gewicht : 0.50000kg
Beschreibung
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
This protein carries a human IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 41.5 kDa. The protein migrates as 45-48 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| AAH69319.1 | |
| 50 μg | |
| Gln 50 - Ser 177 | |
| TNFSF18,AITRL,TL6,hGITRL,GITR Ligand | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 41.5 kDa | |
| Human GITR Ligand, Fc Tag (GIL-H526a) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1). | |
| -20°C | |
| GITR Ligand | |
| Human | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |