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ACROBiosystems Human E-Selectin / CD62E Protein, Fc Tag
Marke: ACROBiosystems CDE-H5250-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
E-Selectin is also known as CD62 antigen-like family member E (CD62E), endothelial-leukocyte adhesion molecule 1 (ELAM-1), or leukocyte-endothelial cell adhesion molecule 2 (LECAM2), a member of the Selectin family, is a 107-115 kDa cell surface glycoprotein.[1] It is transiently expressed on vascular endothelial cells in response to IL-1β and TNFα. E selectin has a cassette structure: an N-terminal, C-type lectin domain, an EGF (epidermal-growth-factor)-like domain, 6 Sushi domain (SCR repeat) units, a transmembrane domain (TM) and an intracellular cytoplasmic tail (cyto).[2] During inflammation, E-selectin plays an important part in recruiting leukocytes to the site of injury. The local release of cytokines IL-1 and TNF-α by damaged cells induces the over-expression of E-selectin on endothelial cells of nearby blood vessels.[3] E-selectin mediates the adhesion of tumor cells to endothelial cells, by binding to E-selectin ligands expressed by neutrophils, monocytes, eosinophils, memory-effector T-like lymphocytes, natural killer cells or cancer cells. Furthermore, a number of studies have reported that levels of E-Selectin may be elevated in subjects with a variety of pathological conditions.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 84.8 kDa. The protein migrates as 96-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_000441.2 | |
| 100 μg | |
| Trp 22 - Phe 556 | |
| SELE,RP1-117P20.2,CD62E,ELAM1,ESEL,LECAM2,E-Selectin | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 84.8 kDa | |
| Human E-Selectin, Fc Tag (CDE-H5250) is expressed from human 293 cells (HEK293). It contains AA Trp 22 - Phe 556 (Accession # NP_000441.2). | |
| -20°C | |
| E-Selectin | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |