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ACROBiosystems Human SMAC / Diablo Protein, His Tag
Marke: ACROBiosystems DIO-H5129-200UG
Weitere Details : Netto-Gewicht : 0.00001kg
Description
Diablo homolog, mitochondrial (DIABLO) is also known as direct IAP-binding protein with low pI and second mitochondria-derived activator of caspase (SMAC), which can interact with BIRC2/c-IAP1, BIRC3/c-IAP2, XIAP/BIRC4, BIRC6/bruce and BIRC7/livin. Acting by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP),DIABLO can also promote apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Also, DIABLO inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Furthermore, DIABLO is defective in the capacity to down-regulate the XIAP/BIRC4 abundance.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 21.7 kDa. The protein migrates as 22 kDa under reducing (R) condition (SDS-PAGE).Specifications
| NP_063940 | |
| 200 μg | |
| Ala 56 - Asp 239 | |
| DIABLO,SMAC | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 21.7 kDa | |
| Human SMAC, His Tag (DIO-H5129) is expressed from E.coli cells. It contains AA Ala 56 - Asp 239 (Accession # NP_063940). | |
| -20°C | |
| SMAC | |
| Human | |
| 20 mM HEPES, 150 mM NaCl, pH7.5 | |
| E.coli | |
| Other Recombinant Proteins |