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ACROBiosystems Human Fas / TNFRSF6 / CD95 Protein, His Tag

MALS verified

Marke:  ACROBiosystems FAS-H5229-50UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15806717

  • 335.90 € / 50 Mikrogramm
Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

The Fas is also known as FAS receptor (FasR), apoptosis antigen 1 (APO-1 or APT), cluster of differentiation 95 (CD95) or tumor necrosis factor receptor superfamily member 6 (TNFRSF6). is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two apoptosis pathways, the other being the mitochondrial pathway. FasR is located on chromosome 10 in humans and 19 in mice. Similar sequences related by evolution (orthologs) are found in most mammals. Fas forms the death-inducing signaling complex (DISC) upon ligand binding. Membrane-anchored Fas ligand trimer on the surface of an adjacent cell causes trimerization of Fas receptor. This event is also mimicked by binding of an agonistic Fas antibody, though some evidence suggests that the apoptotic signal induced by the antibody is unreliable in the study of Fas signaling. To this end, several clever ways of trimerizing the antibody for in vitro research have been employed.Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This allows the adaptor molecule FADD to bind the death domain of Fas through its own death domain. Recently, Fas has also been shown to promote tumor growth, since during tumor progression, it is frequently downregulated or cells are rendered apoptosis resistant. Cancer cells in general, regardless of their Fas apoptosis sensitivity, depend on constitutive activity of Fas. This is stimulated by cancer-produced Fas ligand for optimal growth.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.5 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

AAH12479.1
50 μg
Gln 26 - Asn 173
FAS,ALPS1A,APO1,APT1,CD95,FAS1,FASTM,TNFRSF6,FasR
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>92% as determined by SDS-PAGE
17.5 kDa
Human Fas, His Tag (MALS verified) (FAS-H5229) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Asn 173 (Accession # AAH12479.1).
-20°C
Fas
Human
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote