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ACROBiosystems Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag
Marke: ACROBiosystems IL2-H4210-20UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40). IL-12 is involved in the differentiation of naive T cells into Th1 cells. It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells. It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ. IL-12 plays an important role in the activities of natural killer cells and T lymphocytes. IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels.
Human IL-12B&IL-12A Heterodimer Protein, His Tag&Flag Tag is produced by co-expression of IL-12B and IL-12A, has a calculated MW of 36.6 kDa (IL-12B) and 23.8 kDa (IL-12A). Subunit IL-12B is fused with polyhistidine tag at the C-terminus and subunit IL-12Spezifikation
| NP_002178.2 (IL12B) and NP_000873.2 (IL12A) | |
| 20 μg | |
| Ile 23 - Ser 328 (IL-12 B) and Arg 23 - Ser 219 (IL-12 A) | |
| IL12,p70,Interleukin-12 | |
| Unconjugated | |
| His Tag and Flag Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 36.6 kDa (IL12B) and 23.8 kDa (IL12A) | |
| Human IL-12 B&IL-12; A Heterodimer Protein, His Tag&Flag; Tag (IL2-H4210) is expressed from human 293 cells (HEK293). It contains AA Ile 23 - Ser 328 (IL-12 B) and Arg 23 - Ser 219 (IL-12 A) (Accession # P29460-1 (IL12B) and P29459-1 (IL12A)). | |
| -20°C | |
| IL-12 B and IL-12 A | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |