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ACROBiosystems ActiveMax™ Human Erythropoietin / EPO Protein, Tag Free

Marke:  ACROBiosystems EPO-H4214-20UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15816677

  • 143.96 € / 20 Mikrogramm
Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

Human Erythropoietin (EPO) is also known as EP, erythropoetin or erthropoyetin, and is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. EPO is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. is synthesized by renal peritubular cells in adults, with a small amount being produced in the liver. Regulation is believed to rely on a feed-back mechanism measuring blood oxygenation. Constitutively synthesized transcription factors for EPO, known as hypoxia-inducible factors (HIFs), are hydroxylated and proteosomally digested in the presence of oxygen. It binds to the erythropoietin receptor (EpoR) on the red cell surface and activates a JAK2 cascade. Erythropoietin has its primary effect on red blood cells by promoting red blood cell survival through protecting these cells from apoptosis. It also cooperates with various growth factors involved in the development of precursor red cells. EPO has a range of actions including vasoconstriction-dependent hypertension, stimulating angiogenesis, and inducing proliferation of smooth muscle fibers. It has also been shown that erythropoietin can increase iron absorption by suppressing the hormone hepcidin. Erythropoietin has been shown to interact with the Erythropoietin receptor as its mechanism of action within the body. erythropoietin plays an important role in the brain's response to neuronal injury. EPO is also involved in the wound healing process.

This protein carries no "e;tag"e;. The protein has a calculated MW of 18.4 kDa. The protein migrates as 28-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

AAH93628.1
20 μg
Ala 28 - Arg 193
EPO,EP,MVCD2,Erythropoietin,Erythropoetin,Erthropoyetin,Hematopoietin,Hemopoietin
Unconjugated
Tag Free
Less than 1.0 EU / μg by the LAL method.
Powder
>97% as determined by SDS-PAGE
18.4 kDa
ActiveMax™ Human EPO, Tag Free (EPO-H4214) is expressed from human 293 cells (HEK293). It contains AA Ala 28 - Arg 193 (Accession # AAH93628.1).
-20°C
Erythropoietin
Human
PBS, pH7.4
HEK293
ActiveMax™ Cytokines
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote