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ACROBiosystems Cynomolgus / Rhesus macaque IL-4 R alpha / CD124 Protein, Fc Tag
Marke: ACROBiosystems ILR-C5258-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
IL-4 is a pleiotropic cytokine produced by activated Th2 cells and mast cells, and plays a pivotal role in immune responses. The effects of IL-4 are mediated after binding to high affinity receptor complexes present on hematopoietic as well as non-hematopoietic cells. Hematopoietic cellular responses to IL-4 are mediated by a high affinity receptor complex comprised of the 140 kDa IL4Rα (CD124)subunit and the 70 kDa common cytokine γc chain (CD132).Interleukin 4 Receptor (IL4R) also known as CD124, IL4Rα and BSF receptor, is a type I cytokine receptor produced by activated Th2 cells and mast cells, and plays an important role in Th2- biased immune responses, alternative macrophage activation, mucosal immunity, allergic inflammation, tumor progression, and atherogenesis. A soluble form of the encoded IL4R protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. IL4R can alternatively associate with IL-13Ra1 to form the type II receptor which is responsive to both IL-4 and IL-13. Interleukin-4 receptor has been shown to interact with SHC1.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.4 kDa. The protein migrates as 60-90 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| 50.4 kDa | |
| Cynomolgus / Rhesus macaque IL-4 R alpha, Fc Tag (ILR-C5258) is expressed from human 293 cells (HEK293). It contains AA Met 26 - Arg 232 (Accession # G7Q0S7). In the region Met 26 - Arg 232, the AA sequence of Cynomolgus and Rhesus macaque IL-4 R alpha are homologus. | |
| -20°C | |
| IL-4 R alpha | |
| Cynomolgus Monkey, Rhesus Macaque | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 50 μg | |
| Met 26 - Arg 232 | |
| IL4R,CD124,IL4RA | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |