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ACROBiosystems Hamster PCSK9 Protein, His Tag

Marke:  ACROBiosystems PC9-H52E4-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15817437

  • 2639.24 € / 1 Milligramm
Verfügbar ab: 09-04-2024
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Beschreibung

Beschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).

This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculated
Spezifikation

Spezifikation

13.9 kDa and 59.0 kDa
Hamster PCSK9, His Tag (PC9-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 691 (Accession # G3GTK5).
-20°C
PCSK9
Human
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
1 mg
Gln 30 - Ser 691
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

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Sonderangebote

Sonderangebote