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ACROBiosystems Cynomolgus / Rhesus macaque TIGIT Protein, His Tag

Marke:  ACROBiosystems TIT-C5223-50UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15817777

  • 455.87 € / 50 Mikrogramm
Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 15.2 kDa. The protein migrates as 18-30 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

XP_015300911.1
50 μg
Met 89 - Ile 208
TIGIT,VSIG9,VSTM3
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>90% as determined by SDS-PAGE
15.2 kDa
Cynomolgus / Rhesus macaque TIGIT, His Tag (TIT-C5223) is expressed from human 293 cells (HEK293). It contains AA Met 89 - Ile 208 (Accession # XP_015300911.1). In the region Met 89 - Ile 208, the AA sequence of Cynomolgus and Rhesus macaque TIGIT are homologus.
-20°C
TIGIT
Cynomolgus Monkey, Rhesus Macaque
PBS, pH7.4
HEK293
Immune Checkpoint Proteins
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote