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ACROBiosystems Mouse Dkk-3 Protein, His Tag
Marke: ACROBiosystems DK3-M5226-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 37.1 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_056629.1 | |
| 50 μg | |
| Pro 23 - Ile 349 | |
| DKK3,REIC,RIG | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 37.1 kDa | |
| Mouse Dkk-3, His Tag (DK3-M5226) is expressed from human 293 cells (HEK293). It contains AA Pro 23 - Ile 349 (Accession # NP_056629.1). | |
| -20°C | |
| Dkk-3 | |
| Mouse | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |