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ACROBiosystems Mouse LAIR1 / CD305 Protein, Mouse IgG2a Fc Tag, low endotoxin
low endotoxin
Marke: ACROBiosystems LA1-M5254-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) is constitutively expressed on the majority of human peripheral blood mononuclear leukocytes. LAIR-1 or CD305 is a transmembrane glycoprotein with a single immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. LAIR-1 recruits SHP-1 and SHP-2 phosphatases upon activation, and cross-linking of the LAIR-1 antigen on natural killer (NK) cells results in strong inhibition of NK cell–mediated cytotoxicity. Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation.Diseases associated with LAIR1 include Chronic Active Epstein-Barr Virus Infection and Palindromic Rheumatism.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. The protein migrates as 50-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_001106945.1 | |
| 100 μg | |
| Gln 22 - Tyr 141 | |
| LAIR1,CD305 | |
| Unconjugated | |
| Mouse IgG Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 40.6 kDa | |
| Mouse LAIR-1, Mouse IgG2a Fc Tag, low endotoxin (LA1-M5254) is expressed from human 293 cells (HEK293). It contains AA Gln 22 - Tyr 141 (Accession # Q8BG84-1). | |
| -20°C | |
| LAIR-1 | |
| Mouse | |
| 50 mM Tris, 100 mM Glycine, pH7.5 | |
| HEK293 | |
| Immune Checkpoint Proteins |