Learn More
ACROBiosystems Hamster PCSK9 Protein, His Tag
Marke: ACROBiosystems PC9-H52E4-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculatedSpezifikation
13.9 kDa and 59.0 kDa | |
Hamster PCSK9, His Tag (PC9-H52E4) is expressed from human 293 cells (HEK293). It contains AA Gln 30 - Ser 691 (Accession # G3GTK5). | |
-20°C | |
PCSK9 | |
Hamster | |
PBS, pH7.4 | |
HEK293 | |
Bio-Markers and CD Antigens |
50 μg | |
Gln 30 - Ser 691 | |
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>95% as determined by SDS-PAGE |