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ACROBiosystems Human CD38 Protein, His Tag
MALS verified
Marke: ACROBiosystems CD8-H5224-1MG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
CD antigen CD38 is also known as ADP-ribosyl cyclase 1, which belongs to the ADP-ribosyl cyclase family. CD38 is expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. CD38 is a multifunctional ectoenzyme that catalyzes the synthesis and hydrolysis of cyclic ADP-ribose (cADPR) from NAD+ to ADP-ribose. These reaction products are essential for the regulation of intracellular Ca2+. The loss of CD38 function is associated with impaired immune responses, metabolic disturbances, and behavioral modifications. The CD38 protein is a marker of cell activation. It has been connected to HIV infection, leukemias, myelomas, solid tumors, type II diabetes mellitus and bone metabolism. CD38 has been used as a prognostic marker in leukemia.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 30.7 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_001766 | |
| 1 mg | |
| Val 43 - Ile 300 | |
| CD38,T10,cADPr hydrolase 1 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 30.7 kDa | |
| Human CD38, His Tag (CD8-H5224) is expressed from human 293 cells (HEK293). It contains AA Val 43 - Ile 300 (Accession # NP_001766). | |
| -20°C | |
| CD38 | |
| Human | |
| 50 mM MES, 100 mM NaCl, pH6.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |