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ACROBiosystems Biotinylated Mouse FOLR1 Protein, His, Avitag™

Biotinylated Protein

Marke:  ACROBiosystems FO1-M82E9-200UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15836787

  • 1392.13 € / 200 Mikrogramm


Voraussichtliches Versanddatum: 03-09-2021
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Beschreibung

Beschreibung

Folate Receptor 1 (FOLR1) is also known as Folate receptor alpha, Folate Binding Protein (FBP), FOLR, and is a member of the folate receptor (FOLR) family. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. Mature FOLR1 is an N-glycosylated protein that is anchored to the cell surface by a GPI linkage. FOLR1 is predominantly expressed on epithelial cells and is dramatically upregulated on many carcinomas. FOLR1 is internalized to the endosomal system where it dissociates from its ligand before recycling to the cell surface. A soluble form of FOLR1 can be proteolytically shed from the cell surface into the serum and breast milk. Defects in FOLR1 are the cause of neurodegeneration due to cerebral folate transport deficiency (NCFTD). NCFTD is an autosomal recessive disorder resulting from brain-specific folate deficiency early in life.

This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 26.9 kDa. The protein migrates as 32-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_032060.2
HEK293
Mouse
26.9 kDa
200 µg
Thr 25 - Ser 232
FOLR-1,FBP,FOLR
Precision Avi
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
MABSol™ Biotin Labeled Proteins
Powder
>95% as determined by SDS-PAGE
Biotinylated Mouse FOLR1, His,Avitag (FO1-M82E9) is expressed from human 293 cells (HEK293). It contains AA Thr 25 - Ser 232 (Accession # P35846-1).
-20°C
FOLR1
His Tag and Avi Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate