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ACROBiosystems Human IGFBP-4 Protein, His Tag
Marke: ACROBiosystems IG4-H52E4-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Insulin-like growth factor-binding protein 4 (IGFBP-4) is also known as IGF-binding protein 4, which contains an IGFBP domain and a thyroglobulin type-I domain. IGFBP-4 binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. IGFBP-4 is a unique protein and it consistently inhibits several cancer cells in vivo and in vitro. Its inhibitory action has been shown in vivo in prostate and colon. IGFBP-4 is secreted by all colon cancer cells.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 27.9 kDa. The protein migrates as 33-37 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_001543.2 | |
| 50 μg | |
| Asp 22 - Glu 258 | |
| IGFBP4,IBP-4 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 27.9 kDa | |
| Human IGFBP-4, His Tag (IG4-H52E4) is expressed from human 293 cells (HEK293). It contains AA Asp 22 - Glu 258 (Accession # P22692-1). | |
| -20°C | |
| IGFBP-4 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |