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ACROBiosystems Human IL-1 beta / IL-1F2 Protein, Tag Free
MALS verified
Marke: ACROBiosystems ILB-H4110-20UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Interleukin-1 beta (IL-1β) is also known as catabolin, is a cytokine protein that in humans is encoded by the IL1B gene. IL-1β precursor is cleaved by caspase 1 (interleukin 1 beta convertase). Cytosolic thiol protease cleaves the product to form mature IL-1 beta.IL1β are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1α and IL1β are regulated independently, they bind to the same receptor and exert identical biological effects. IL-1β is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.
This protein carries no "e;tag"e;. The protein has a calculated MW of 17.5 kDa. The protein migrates as 17 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| NP_000567.1 | |
| 20 μg | |
| Ala 117 - Ser 269 | |
| IL1B,IL-1 BETA,IL1F2,IL-1β | |
| Unconjugated | |
| Tag Free | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 17.5 kDa | |
| Human IL-1 beta, Tag Free (ILB-H4110) is expressed from E.coli cells. It contains AA Ala 117 - Ser 269 (Accession # P01584-1). | |
| -20°C | |
| IL-1 beta | |
| Human | |
| PBS, pH7.4 | |
| E.coli | |
| Cytokines and Growth Factors |