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ACROBiosystems Human CD58 / LFA-3 Protein, Fc Tag
Marke: ACROBiosystems LF3-H5256-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
CD antigen CD58 is also known as Lymphocyte function-associated antigen 3 (LFA-3). CD58 is a cell adhesion molecule expressed on Antigen Presenting Cells (APC), particularly macrophages. CD58 /LFA3 is ligand of the T-lymphocyte CD2 glycoprotein, which binds to CD2 (LFA-2) [3] on T cells and is important in strengthening the adhesion between the T cells and Professional Antigen Presenting Cells. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells. Polymorphisms in the CD58 gene are associated with increased risk for multiple sclerosis.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 48.1 kDa. As a result of differtent glycosylation, the protein migrates as 60-75 kDa under reducing (R) condition, and 125-150 kDa under non-reducing (NR) condiSpezifikation
| AAH05930 | |
| 100 μg | |
| Phe 29 - Arg 215 | |
| CD58,LFA3,Ag3 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 48.1 kDa | |
| Human CD58, Fc Tag (LF3-H5256) is expressed from human 293 cells (HEK293). It contains AA Phe 29 - Arg 215 (Accession # AAH05930). | |
| -20°C | |
| CD58 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |