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ACROBiosystems Human PCSK9 (D374Y) Protein, His Tag

Marke:  ACROBiosystems PCY-H5225-50UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15837447

  • 335.90 € / 50 Mikrogramm
Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

Proprotein convertase subtilisin/kexin type 9 (PCSK9), is an enzyme which in humans is encoded by the PCSK9 gene. This gene encodes a proprotein convertase belonging to the proteinase K subfamily of the secretory subtilase family. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).Especially,the D374Y mutation results in higher affinity of PCSK9 for LDLR.

This protein carries a polyhistidine tag at the C-terminus. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent interactions and with a calculated
Spezifikation

Spezifikation

AAI66619.1 (D374Y)
50 μg
Gln 31 - Gln 692
PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9
Unconjugated
His Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>92% as determined by SDS-PAGE
13.8 kDa and 58.2 kDa
Human PCSK9 (D374Y), His Tag (PCY-H5225) is expressed from human 293 cells (HEK293). It contains AA Gln 31 - Gln 692 (Accession # Q8NBP7-1 (D374Y)).
-20°C
PCSK9
Human
PBS, pH7.4
HEK293
Bio-Markers and CD Antigens
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote