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ACROBiosystems Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) Envelope Glycoprotein (GP), His Tag
Marke: ACROBiosystems ZE5-V5221-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
EBOV encodes seven structural proteins: nucleoprotein (NP), polymerase cofactor (VP35), (VP40), GP, transcription activator (VP30), VP24, and RNA polymerase (L). GP protein contains 160-kDa envelope-attached glycoprotein (GP) and a 110 kDa secreted glycoprotein (sGP). GP is a class I fusion protein which assembles as trimers on viral surface and plays an important role in virus entry and attachment. Mature GP is a disulfide-linked heterodimer formed by two subunits, GP1 and GP2, which are generated from the proteolytical process of GP precursor (pre-GP) by cellular furin during virus assembly . GP1 is responsible for binding to the receptor(s) on target cells. Interacts with CD209/DC-SIGN and CLEC4M/DC-SIGNR which act as cofactors for virus entry into the host cell. GP2 acts as a class I viral fusion protein. GP1,2 mediates endothelial cell activation and decreases endothelial barrier function. sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha.
Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) GP, His Tag, containing GP1 and GP2, is fused with a polyhistidine tag at the C-terminus, and has a calculated MW of 67.2 kDa. The reducing (R) protein migrates as 21-23 kDa (GP2-delta) and 110-120 kDa (GPSpezifikation
| AAQ55048.1 | |
| 100 μg | |
| Ile 33 - Asp 637 | |
| GP,Envelope glycoprotein,GP(1,2) | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >85% as determined by SDS-PAGE |
| 67.2 kDa | |
| Ebolavirus EBOV (subtype Zaire, strain Kikwit-95) GP, His Tag (ZE5-V5221) is expressed from human 293 cells (HEK293). It contains AA Ile 33 - Asp 637 (Accession # AAQ55048.1). | |
| -20°C | |
| Glycoprotein / GP (virus) | |
| Ebolavirus | |
| PBS, pH7.4 | |
| HEK293 | |
| Viral Proteins |