missing translation for 'onlineSavingsMsg'
Learn More
Learn More
ACROBiosystems Mouse ADAM17 / TACE / CD156b Protein, His Tag
Marke: ACROBiosystems AD7-M52H1-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17), a member of the ADAM protein family of disintegrins and metalloproteases, is also known as TNF-alpha convertase, TNF-alpha-converting enzyme and CD156b, which contains one disintegrin domain and one peptidase M12B domain. ADAM17 can cleave the membrane-bound precursor of TNF-alpha to its mature soluble form. ADAM17 is also responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity) and proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Furthermore, ADAM17 acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 63.4 kDa. The protein migrates as 19 kDa and 20 kDa (Propeptide), 55-66 kDa (Mature-ADAM17) and 75-94 kDa (Pro-ADAM17) under reducing (R) condition (SDS-PAGE)Spezifikation
| 63.4 kDa | |
| Mouse ADAM17, His Tag (AD7-M52H1) is expressed from human 293 cells (HEK293). It contains AA Pro 18 - Asp 563 (Accession # Q9Z0F8). | |
| -20°C | |
| ADAM17 | |
| Mouse | |
| 50 mM MES, 150 mM NaCl, pH6.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |
| 50 μg | |
| Pro 18 - Asp 563 | |
| ADAM17,TACE,CD156b | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >85% as determined by SDS-PAGE |