missing translation for 'onlineSavingsMsg'
Learn More

ACROBiosystems Biotinylated Human B7-1 / CD80 Protein, Avitag™,His Tag

Recommended for biopanning

Marke:  ACROBiosystems B71-H82E9-25UG

Weitere Details : Netto-Gewicht : 0.00001kg

 Weitere Artikel aus diesem Sortiment

Artikelnummer. 15855947

  • 419.88 € / 25 Mikrogramm
Verfügbar ab: 09-04-2024
Sie sich ein, um den Lagerbestand zu sehen

Bitte Sie sich an, um diesen Artikel zu kaufen. Sie benötigen ein Web-Konto? Registrieren Sie sich noch heute!


Beschreibung

Beschreibung

B7-1 and B7-2, together with their receptors CD28 and CTLA-4, constitute one of the dominant co-stimulatory pathways that regulate T- and B-cell responses. Although both CTLA-4 and CD28 can bind to the same ligands, CTLA-4 binds to B7-1 and B7-2 with a 20 - 100 fold higher affinity than CD28 and is involved in the down regulation of the immune response.B-lymphocyte activation antigen B7-1 (referred to as B7) also known as cluster of Differentiation 80 (CD80), is a member of cell surface immunoglobulin superfamily and is expressed on activated B cells, activated T cells, macrophages and dendritic cells. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation). CD80 works in tandem with CD86 to prime T cells. CD80 plays a role in induction of innate immune responses by activating NF-κB-signaling pathway in macrophages. CD80 is thus regarded as promising therapeutic targets for autoimmune diseases and various carcinomas.

This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. The protein has a calculated MW of 26.5 kDa. The protein migrates as 44-54 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_005182.1
25 μg
Val 35 - Asn 242
CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7
Precision Avi
His Tag and Avi Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
26.5 kDa
Biotinylated Human B7-1, Avitag,His Tag (recommended for biopanning) (B71-H82E9) is expressed from human 293 cells (HEK293). It contains AA Val 35 - Asn 242 (Accession # P33681-1).
-20°C
B7-1
Human
PBS, pH7.4
HEK293
MABSol™ Biotin Labeled Proteins
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote