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ACROBiosystems Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (BLI verified)
Marke: ACROBiosystems FCM-C5284-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.
Cynomolgus / Rhesus macaque FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (BLI verified), produced by co-expression of FCGRT and B2M, has a calculated MW of 32.3 kDa (FCGRT) and 13.1 kDa (B2M). Subunit FCGRT is fused with a polyhistidine tag at theSpezifikation
| 32.3 kDa (FCGRT), 13.1 kDa (B2M) | |
| Cynomolgus / Rhesus macaque FCGRT&B2M; Heterodimer Protein, His Tag&Strep; II Tag (BLI verified) (FCM-C5284), is expressed from human 293 cells (HEK293). It contains AA Ala 24 - Ser 297 (FCGRT) and Ile 21 - Met 119 (B2M) (Accession # Q8SPV9-1 (FCGRT) and Q8SPW0-1 (B2M)). In the region Ala 24 - Ser 297 (FCGRT) and Ile 21 - Met 119 (B2M), the AA sequence of Cynomolgus and Rhesus macaque FcRn (FCGRT and B2M) are homologus. | |
| -20°C | |
| FcRn (FCGRT and B2M) | |
| Cynomolgus Monkey, Rhesus Macaque | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Fc Receptors |
| 50 μg | |
| Ala 24 - Ser 297 (FCGRT) and Ile 21 - Met 119 (B2M) | |
| FcRn,FCGRT and B2M | |
| Unconjugated | |
| His Tag and Strep Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |