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ACROBiosystems Mouse IL-23 alpha&IL-12 beta Heterodimer Protein, His Tag&Tag Free
Marke: ACROBiosystems ILB-M52W7-1MG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Interleukin-23 subunit alpha (IL-23 alpha) can associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Mouse IL-23A&IL-12B Heterodimer Protein, His Tag&Tag Free, produced by co-expression of IL-23A and IL-12B, has a calculated MW of 20.5 kDa (IL-23A) and 35.8 kDa (IL-12B). Subunit IL-23A is fused with a polyhistidine tag at the N-terminus and subunit IL-12Spezifikation
NP_112542.1 (IL23A) and NP_032378.1 (IL12B) | |
1 mg | |
Val 22 - Ala 196 (IL23A) and Met 23 - Ser 335 (IL12B) | |
IL-23 alpha and IL-12 beta | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |
20.5 kDa (IL23A) and 35.8 kDa (IL12B) | |
Mouse IL-23 A&IL-12; B Heterodimer Protein, His Tag&Tag; Free (ILB-M52W7) is expressed from human 293 cells (HEK293). It contains AA Val 22 - Ala 196 (IL23A) and Met 23 - Ser 335 (IL12B) (Accession # Q9EQ14-1 (IL23A) and P43432-1 (IL12B)). | |
-20°C | |
IL23A and IL12B | |
Mouse | |
PBS, pH7.4 | |
HEK293 | |
Cytokines and Growth Factors |