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ACROBiosystems Mouse Fc gamma RIII / CD16 Protein, His Tag (SPR & BLI verified)
Marke: ACROBiosystems CDA-M52H8-100UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
CD16 is a low affinity Fc receptor, and has been identified as Fc receptors FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc portion of IgG antibodies. CD16 encoded by two different highly homologous genes in a cell type-specific manner.CD16 is found on the surface of natural killer cells, neutrophil polymorphonuclear leukocytes, monocytes and macrophages.CD16a antigen is also known as Low affinity immunoglobulin gamma Fc region receptor III-A, Fc-gamma RIII-alpha. CD16b is a low-affinity, GPI-linked receptor expressed by neutrophils and eosinophils, whereas CD16a is an intermediate affinity polypeptide-anchored transmembrane glycoprotein expressed natural killer cells, macrophages, subpopulation of T-cells, immature thymocytes and placentaltrophoblasts.CD16a is involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibodydependent cytotoxicity and clearance of immune complexes. Aberrant expression or mutations of CD16a is implicated in susceptibility to recurrent viral infections, systemic lupus erythematosus, and alloimmune neonatal neutropenia.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 23.0 kDa. The protein migrates as 36-45 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| 23.0 kDa | |
| Mouse CD16, His Tag (SPR and BLI verified) (CDA-M52H8) is expressed from human 293 cells (HEK293). It contains AA Leu 32 - Thr 215 (Accession # Q5D5I8). | |
| -20°C | |
| Fc gamma RIII / CD16 | |
| Mouse | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Fc Receptors |
| 100 μg | |
| Leu 32 - Thr 215 | |
| FCGR3 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by reduced SDS-PAGE |