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ACROBiosystems Human ICAM-1 / CD54 Protein, His Tag

Marke:  ACROBiosystems IC1-H52H5-100UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15866957

  • 353.08 € / 100 Mikrogramm

Voraussichtliches Versanddatum: 14-10-2021

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Beschreibung

Beschreibung

Inter-Cellular Adhesion Molecule 1 (ICAM-1) is also known as Cluster of Differentiation 54 (CD54), is a member of the immunoglobulin superfamily, and is a cell surface glycoprotein which is typically expressed in low concentrations on endothelial cells and cells of the immune system. The protein encoded by this gene is a type of intercellular adhesion molecule continuously present in low concentrations in the membranes of leukocytes and endothelial cells. Upon cytokine stimulation, the concentrations greatly increase. ICAM-1 can be induced by interleukin-1 (IL-1) and tumor necrosis factor alpha (TNFα) and is expressed by the vascular endothelium, macrophages, and lymphocytes. ICAM-1 is a ligand for LFA-1 (integrin), a receptor found on leukocytes. When activated, leukocytes bind to endothelial cells via ICAM-1/LFA-1 and then transmigrate into tissues. ICAM-1 has been implicated in subarachnoid hemorrhage (SAH). Levels of ICAM-1 are shown to be significantly elevated in patients with SAH over control subjects in many studies. ICAM-1 expressed by respiratory epithelial cells is also the binding site for rhinovirus, the causative agent of most common colds.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 51.4 kDa. The protein migrates as 60-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

AAH15969.1
HEK293
Human
51.4 kDa
100 µg
Gln 28 - Glu 480
ICAM1,BB2,CD54,P3.58
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Bio-Markers and CD Antigens
Powder
>95% as determined by SDS-PAGE
Human ICAM-1, His Tag (IC1-H52H5) is expressed from human 293 cells (HEK293). It contains AA Gln 28 - Glu 480 (Accession # P05362-1).
-20°C
ICAM-1
His Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation
Zertifikate