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ACROBiosystems Biotinylated Human Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer Protein, His, Avitag™&Tag Free
Biotinylated Protein
Marke: ACROBiosystems IT6-H82E4-25UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Integrin alpha V beta 6 is a heterodimer of beta-6 associating with alpha-V. Integrin alpha-V beta-6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. Also, Integrin alpha-V beta-6 acts as a receptor for coxsackievirus A9 and coxsackievirus B1 as well as herpes simplex virus-1/HHV-1. Furthermore, it binds the TGF-beta latency‐associated peptide (LAP) and activates TGF-beta 1 or TGF-beta 3 from large latent complexes. This activation requires interaction with LTBP-1 and fibronectin, and is enhanced by PAR-1.
Biotinylated Human ITGAV&ITGB6 Heterodimer Protein, His,Avitag&Tag Free, produced by co-expression of ITGAV and ITGB6, has a calculated MW of 114.7 kDa (ITGAV) and 79.6 kDa (ITGB6). Subunit ITGAV is fused with an acidic tail at the C-terminus and followeSpezifikation
| NP_002201.1 (ITGAV) and AAI21179.1 (ITGB6) | |
| 25 μg | |
| Phe 31 - Val 992 (ITGAV) and Gly 22 - Asn 707 (ITGB6) | |
| Integrin alpha V beta 6,ITGAVandITGB6 | |
| Precision Avi | |
| His Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by reduced SDS-PAGE |
| 114.7 kDa (ITGAV) and 79.6 kDa (ITGB6) | |
| Biotinylated Human ITGAV&ITGB6; Heterodimer Protein, His,AviTag&Tag; Free (IT6-H82E4) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 992 (ITGAV) and Gly 22 - Asn 707 (ITGB6) (Accession # NP_002201.1 (ITGAV) and AAI21179.1 (ITGB6)). | |
| -20°C | |
| Integrin alpha V beta 6 | |
| Human | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |