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ACROBiosystems Human Prolactin R / PRLR Protein, Fc Tag

Marke:  ACROBiosystems PRP-H5251-100UG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15867547

  • 419.88 € / 100 Mikrogramm
Verfügbar ab: 08-04-2024
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Beschreibung

Beschreibung

As a transmembrane receptor, the prolactin receptor (PRL-R) interacts with prolactin. In addition, the PRL-R also binds and is activated by growth hormone (GH) and human placental lactogen (hPL). Preclinical investigations, epidemiological studies and analyses of tissue specimens from patients strongly support the contribution of prolactin receptor (PRLR) signaling to breast and prostate tumorigenesis and cancer progression. Moreover, The PRLR has been found to be essential for lobuloalveolar maturation of the mammary glands during pregnancy, as evidenced by the fact that PRLR knockout mice show severely impaired development of lobuloalveolar structures.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 51.0 kDa. The protein migrates as 64 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_000940.1
100 μg
Gln 25 - Asp 234
Prolactin R,PRLR,PRL-R
Unconjugated
Fc Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
51.0 kDa
Human Prolactin R, Fc Tag (PRP-H5251) is expressed from human 293 cells (HEK293). It contains AA Gln 25 - Asp 234 (Accession # P16471-1).
-20°C
Prolactin R
Human
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Cytokines and Growth Factors
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote