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ACROBiosystems Human TIGIT Protein, Fc Tag

MALS verified

Marke:  ACROBiosystems TIT-H5254-1MG

Weitere Details : Netto-Gewicht : 0.00001kg

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Artikelnummer. 15867777

  • 2330.32 € / 1 Milligramm

Verfügbar ab
02-07-2021

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Beschreibung

Beschreibung

T-cell immunoreceptor with Ig and ITIM domains (TIGIT) is also known as V-set and immunoglobulin domain-containing protein 9 (VSIG9), V-set and transmembrane domain-containing protein 3 (VSTM3),which belongs to single-pass type I membrane protein containing an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed at low levels on peripheral memory and regulatory CD4+ T-cells and NK cells and is up-regulated following activation of these cells (at protein level). TIGIT binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells.

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 39.7 kDa. The protein migrates as 45-54 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Spezifikation

Spezifikation

NP_776160.2
HEK293
Human
39.7 kDa
1 mg
Met 22 - Pro 141
TIGIT,VSIG9,VSTM3
Unconjugated
50 mM Tris, 100 mM Glycine, 25 mM Arginine, 10 mM NaCl, pH7.5
Less than 1.0 EU / µg by the LAL method.
Immune Checkpoint Proteins
Powder
>95% as determined by SDS-PAGE
Human TIGIT, Fc Tag (TIT-H5254) is expressed from human 293 cells (HEK293). It contains AA Met 22 - Pro 141 (Accession # Q495A1-1).
-20°C
TIGIT
Fc Tag
Videos
Sicherheitsdatenblatt (SDS)
Dokumentation