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ACROBiosystems Human UCH-L1 Protein, His Tag
Marke: ACROBiosystems UC1-H5140-50UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) ,a member of the peptidase C12 family, is also known as neuron cytoplasmic protein 9.5 (PGP 9.5) and ubiquitin thioesterase L1.About 30% of total UCHL1 is associated with membranes in brain. UCHL1 is involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also,UCHL1 can bind to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer of UCHL1 may have ATP-independent ubiquitin ligase activity. Furthermore, the mutations of UCHL1 gene can result in parkinson disease 5.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 25.7 kDa. The protein migrates as 27-28 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| NP_004172 | |
| 50 μg | |
| Gln 2 - Ala 223 | |
| UCHL1,PGP9.5 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 25.7 kDa | |
| Human UCH-L1, His Tag (UC1-H5140) is expressed from E.coli cells. It contains AA Gln 2 - Ala 223 (Accession # NP_004172). | |
| -20°C | |
| UCH-L1 | |
| Human | |
| 50 mM Tris, 150 mM Nacl, pH8.0 | |
| E.coli | |
| Other Recombinant Proteins |