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ACROBiosystems Biotinylated Mouse PCSK9 Protein, Avitag™,His Tag
Biotinylated Protein
Marke: ACROBiosystems PC9-M82E1-25UG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons. Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).
This protein carries an Avi tag (Avitag™) at the C-terminus, followed by a polyhistidine tag. This protein undergoes autocatalytic cleavage to release the pro-peptide and mature chain. The pro-peptide and mature chain are associated through non‐covalent iSpezifikation
| AAH38085.1 | |
| 25 μg | |
| Gln 35 - Gln 694 | |
| PCSK9,FH3,HCHOLA3,LDLCQ1,NARC1,PC9 | |
| Precision Avi | |
| His Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 13.9 kDa and 61.0 kDa | |
| MABSol™ Biotinylated Mouse PCSK9, Avitag,His Tag (PC9-M82E1) is expressed from human HEK293 cells. It contains AA Gln 35 - Gln 694 (Accession # AAH38085.1). | |
| -20°C | |
| PCSK9 | |
| Mouse | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |