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ACROBiosystems Human TFPI-2 Protein, His Tag
Marke: ACROBiosystems TF2-H5227-1MG
Weitere Details : Netto-Gewicht : 0.00001kg
Beschreibung
Tissue Factor Pathway Inhibitor 2 (TFPI2) is also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF1), is a member of the Kunitz-type serine proteinase inhibitor family, is a structural homologue of tissue factor pathway inhibitor (TFPI). TFPI2 is highly abundant in the full-term placenta and widely expressed in umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy. TFPI2 may play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa and has no effect on thrombin. Reduced synthesis of TFPI-2 has been related to numerous pathophysiological processes such as inflammation, angiogenesis, atherosclerosis, retinal degeneration and tumor growth / metastasis.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 22.7 kDa. The protein migrates as 26-32 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_006519.1 | |
| 1 mg | |
| Asp 23 - Lys 213 | |
| TFPI2,PP5,REF1 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 22.7 kDa | |
| Human TFPI-2, His Tag (TF2-H5227) is expressed from human 293 cells (HEK293). It contains AA Asp 23 - Lys 213 (Accession # NP_006519.1). | |
| -20°C | |
| TFPI-2 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Other Recombinant Proteins |