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ACROBiosystems Biotinylated Human CEACAM-6 / CD66c Protein, His, Avitag™
Biotinylated Protein
Marke: ACROBiosystems CE6-H82E7-25ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) (CEACAM6) is also known as CD66c (Cluster of Differentiation 66c), CEAL, NCA, and is one of seven human CEACAM family members within the immunoglobulin superfamily. In humans, CEACAMs include type I transmembrane proteins (CEACAM1, CEACAM3, and CEACAM4) and GPI-linked molecules (CEACAM5 through CEACAM8). There is no human CEACAM2. CEACAM 6 contains one N-terminal V-type Ig-like domain (N domain), followed by two C2-type Ig-like domains. It shows considerable glycosylation, including (sialyl) LewisX, which mediates binding to E-selectin, galectins and some bacterial fimbrae. CEACAM-6 is expressed by granulocytes and their progenitors. It is also expressed by epithelia of various organs and is upregulated in pancreatic and colon adenocarcinomas, as well as hyperplastic polyps. Resistance to adhesion-related apoptosis in tumor cells is conferred in the condition of CEACAM6 overexpression.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 34.9 kDa. The protein migrates as 55-66 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| 34.9 kDa | |
| Biotinylated Human CEACAM-6, His,Avitag (CE6-H82E7) is expressed from human 293 cells (HEK293). It contains AA Lys 35 - Gly 320 (Accession # P40199-1). | |
| -20°C | |
| CEACAM-6 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| MABSol™ Biotin Labeled Proteins |
| 25 μg | |
| Lys 35 - Gly 320 | |
| CEACAM6,CD66c,CEAL,NCA | |
| Precision Avi | |
| His Tag and Avi Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |