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ACROBiosystems Human Complement C5 (R885H) Protein, His Tag
Marke: ACROBiosystems CO5-H52Hx-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.
This protein carries a polyhistidine tag at the C-terminus.The mature form of Complement C5 is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. Each α and β chain has a calculated MW of 73.9 kDa (β chain) and 114.7 kDa (αSpezifikation
NP_001726.2 | |
100 μg | |
Gln 19 - Cys 1676 | |
Complement C5,C5,CPAMD4 | |
Unconjugated | |
His Tag | |
Less than 1.0 EU / μg by the LAL method. | |
Powder | |
>90% as determined by SDS-PAGE |
73.9 kDa (β chain) and 114.7 kDa (α chain) | |
Human Complement C5 (R885H), His Tag (CO5-H52Hx) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Cys 1676 (Accession # P01031-1 (R885H)). | |
-20°C | |
Complement C5 | |
Human | |
PBS, pH7.4 | |
HEK293 | |
Cytokines and Growth Factors |