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ACROBiosystems Human IL-15 Protein, Tag Free
SPR verified
Marke: ACROBiosystems IL5-H4117-50ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Interleukin 15 is also known as IL15, IL-15, and is a cytokine with structural similarity to IL-2. Like IL-2, IL-15 binds to and signals through the IL-2/IL-15 beta chain (CD122) and the common gamma chain (gamma-C, CD132). IL-15 is secreted by mononuclear phagocytes (and some other cells) following infection by virus(es). This cytokine induces cell proliferation of natural killer cells; cells of the innate immune system whose principal role is to kill virally infected cells. Interleukin 15 (IL-15) regulates T and natural killer (NK) cell activation and proliferation. Survival signals that maintain memory T cells in the absence of antigen are provided by IL-15. This cytokine is also implicated in NK cell development. In rodent lymphocytes, IL-15 prevents apoptosis by inducing an apoptosis inhibitor, BCL2L1/BCL-x(L). IL-15 has been shown to enhance the anti-tumor immunity of CD8+ T cells in pre-clinical models. A phase I clinical trial to evaluate the safety, dosing, and anti-tumor efficacy of IL-15 in patients with metastatic melanoma and renal cell carcinoma (kidney cancer) has begun to enroll patients at the National Institutes of Health.
This protein carries no "e;tag"e;. The protein has a calculated MW of 12.8 kDa. The protein migrates as 13 kDa under reducing (R) condition (SDS-PAGE).Spezifikation
| AAH18149.1 | |
| 50 μg | |
| Asn 49 - Ser 162 | |
| IL-15,Interleukin-15,MGC9721 | |
| Unconjugated | |
| Tag Free | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 12.8 kDa | |
| Human IL-15, Tag Free (IL5-H4117) is expressed from E.coli cells. It contains AA Asn 49 - Ser 162 (Accession # P40933-1). | |
| -20°C | |
| IL-15 | |
| Human | |
| PBS, pH7.4 | |
| E.coli | |
| Cytokines and Growth Factors |