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ACROBiosystems Mouse Integrin alpha V beta 8 (ITGAV&ITGB8) Heterodimer Protein, His Tag&Tag Free
Marke: ACROBiosystems IT8-M52W6-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Integrin alpha V beta 8 (ITGAV & ITGB8 or ITGAVB8) is expressed in yolk sac, placenta, brain perivascular astrocytes, Schwann cells, renal glomerular mesangial cells and pulmonary epithelial cells. Unlike other alpha V integrins, ITGAVB8 does not appear to assume different activation states, and the cytoplasmic tail does not connect to the cytoskeleton. It binds ligands containing an RGD motif, including vitronectin, fibrin and the latency associated peptide (LAP) of the latent TGF-beta complex. High affinity binding of alpha V beta 8 to LAP allows proteolytic cleavage by MT1-MMP, which releases active TGF-beta. This mechanism differs from that of alpha V beta 6, the other alpha V integrin which can activate TGF-beta from latency through non-proteolytic mechanisms. Downstream effects of TGF-beta activation include control of cell growth and associated vascularization.
Mouse ITGAV&ITGB8 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGAV and ITGB8, has a calculated MW of 112.5 kDa (ITGAV) and 77.5 kDa (ITGB8). Subunit ITGAV is fused with an acidic tail at the C-terminus and followed by a polyhistidSpezifikation
| NP_032428.2 (ITGAV) and NP_796264.2 (ITGB8) | |
| 100 μg | |
| Phe 31 - Val 988 (ITGAV) and Gly 22 - Leu 681 (ITGB8) | |
| Integrin alpha V beta 8,ITGAVandITGB8 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by reduced SDS-PAGE |
| 112.5 kDa (ITGAV) and 77.5 kDa (ITGB8) | |
| Mouse ITGAV&ITGB8; Heterodimer Protein, His Tag&Tag; Free (IT8-M52W6) is expressed from human 293 cells (HEK293). It contains AA Phe 31 - Val 988 (ITGAV) and Gly 22 - Leu 681 (ITGB8) (Accession # P43406-1 (ITGAV) and Q0VBD0-1 (ITGB8)). | |
| -20°C | |
| Integrin alpha V beta 8 | |
| Mouse | |
| 50 mM Tris, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |