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ACROBiosystems Human LRP-5 Protein, Mouse IgG2a Fc Tag
Marke: ACROBiosystems LR5-H5254-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Low-density lipoprotein receptor-related protein 5(LRP-5) is also known as BMND1, EVR1, EVR4, HBM, LR3, LRP7, OPPG, OPTA1, VBCH2, LDL receptor related protein 5 and PCLD4. LRP5 is a transmembrane low-density lipoprotein receptor that shares a similar structure with LRP6. LRP5 acts as a co-receptor with LRP6 and the Frizzled protein family members for transducing signals by Wnt proteins through the canonical Wnt pathway. This protein plays a key role in skeletal homeostasis. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation causes osteoporosis-pseudoglioma (decrease in bone mass), while a gain-of-function mutation causes drastic increases in bone mass.
This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 96.6 kDa. The protein migrates as 110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_002326.2 | |
| 100 μg | |
| Glu 644 - Gln 1263 | |
| LRP5,LRP-5,LRP-7,LRP7,LR3 | |
| Unconjugated | |
| Mouse IgG Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 96.6 kDa | |
| Human LRP-5, Mouse IgG2a Fc Tag (LR5-H5254) is expressed from human 293 cells (HEK293). It contains AA Glu 644 - Gln 1263 (Accession # O75197-1). | |
| -20°C | |
| LRP-5 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Other Recombinant Proteins |