missing translation for 'onlineSavingsMsg'
Learn More
Learn More
ACROBiosystems Human HMGB1 Protein, Mouse IgG2a Fc Tag, low endotoxin
low endotoxin
Marke: ACROBiosystems HM1-H5255-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
High-mobility group protein B1 (HMGB1) is also known as high-mobility group protein 1 (HMG-1) and amphoterin, is a member of the HMGB family consisting of three members, HMGB1, HMGB2 and HMGB3. HMGB1 is a non-histone architectural chromosomal protein ubiquitously present in all vertebrate nuclei and binds double-stranded DNA without sequence specificity. The mechanism of inflammation and damage is binding to TLR4, which mediates HMGB1-dependent activation of macrophage cytokine release. This positions HMGB1 at the intersection of sterile and infectious inflammatory responses. HMGB1 has been studied as a DNA vaccine adjuvant and a target for cancer therapy.
This protein carries a mouse IgG2a Fc tag at the N-terminus. The protein has a calculated MW of 51.6 kDa. The protein migrates as 60 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_002119.1 | |
| 100 μg | |
| Gly 2 - Glu 215 | |
| HMGB1,HMG1,HMG3,SBP-1 | |
| Unconjugated | |
| Mouse IgG Fc Tag | |
| Less than 0.1 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 51.6 kDa | |
| Human HMGB1, Mouse IgG2a Fc Tag, low endotoxin (HM1-H5255) is expressed from human 293 cells (HEK293). It contains AA Gly 2 - Glu 215 (Accession # P09429-1). | |
| -20°C | |
| HMGB1 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |