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ACROBiosystems Human IL-2 Protein, His Tag
Marke: ACROBiosystems IL2-H52H8-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Interleukin-2 (IL-2) is an interleukin, a type of cytokine immune system signaling molecule, which is a leukocytotrophic hormone that is instrumental in the body's natural response to microbial infection and in discriminating between foreign (non-self) and self. IL-2 mediates its effects by binding to IL-2 receptors, which are expressed by lymphocytes, the cells that are responsible for immunity. Mature human IL-2 shares 56% and 66% aa sequence identity with mouse and rat IL-2, respectively. Human and mouse IL-2 exhibit crossspecies activity. The receptor for IL-2 consists of three subunits that are present on the cell surface in varying preformed complexes. IL-2 is also necessary during T cell development in the thymus for the maturation of a unique subset of T cells that are termed regulatory T cells (T-regs). After exiting from the thymus, T-Regs function to prevent other T cells from recognizing and reacting against “self antigens”, which could result in “autoimmunity”. T-Regs do so by preventing the responding cells from producing IL-2. Thus, IL-2 is required to discriminate between self and non-self, another one of the unique characteristics of the immune system.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.3 kDa. The protein migrates as 18 kDa and 19 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_000577.2 | |
| 100 μg | |
| Ala 21 - Thr 153 | |
| IL2,TCGF,lymphokine,Interleukin 2 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 17.3 kDa | |
| Human IL-2, His Tag (IL2-H52H8) is expressed from human 293 cells (HEK293). It contains AA Ala 21 - Thr 153 (Accession # P60568-1). | |
| -20°C | |
| IL-2 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |