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ACROBiosystems Cynomolgus Siglec-15 / CD33L3 Protein, Fc Tag
Marke: ACROBiosystems SG5-C5253-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Siglec-15 is a DAP12-associated immunoreceptor, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. Siglecs are cell surface proteins that bind sialic acid. They are found primarily on the surface of immune cells and are a subset of the I-type lectins. Siglec-15 consisting of immunoglobulin (Ig)-like domains, transmembrane domain and a short cytoplasmic tail. Siglec-15 is that recognizes sialylated glycans and regulates osteoclast differentiation. Siglec-15 is a potential therapeutic target for osteoporosis and plays a conserved regulatory role in the immune system of vertebrates.
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 52.7 kDa. The protein migrates as 60-65 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| 52.7 kDa | |
| Cynomolgus Siglec-15, Fc Tag (SG5-C5253) is expressed from human 293 cells (HEK293). It contains AA Phe 20 - Thr 263 (Accession # A0A2K5UY47-1). | |
| -20°C | |
| Siglec-15 | |
| Cynomolgus Monkey | |
| 50 mM Tris, 100 mM Glycine, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Other Recombinant Proteins |
| 100 μg | |
| Phe 20 - Thr 263 | |
| CD33 antigen-like 3,SIGLEC-15,CD33L3,sialic acid-binding Ig-like lectin 15,Siglec15,Siglec-15 | |
| Unconjugated | |
| Fc Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |