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ACROBiosystems Mouse TRAIL R2 / DR5 / TNFRSF10B Protein, His Tag
Marke: ACROBiosystems TR2-M52H5-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Tumor necrosis factor receptor superfamily member 10B (TNFRSF10B) is also known as TNF-related apoptosis-inducing ligand receptor 2 (TRAILR2), Death receptor 5 (DR5), CD262, KILLER, is a member of the TNF-receptor superfamily, and contains an intracellular death domain. TNFRSF10B / DR-5 is widely expressed in adult and fetal tissues; very highly expressed in tumor cell lines. TRAILR2 / CD262 / DR5 is the receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD (a death domain containing adaptor protein) of TRAIL-R2 / TNFRSF10B recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. CD262 / DR5 Promotes the activation of NF-kappa-B. DR5 is essential for ER stress-induced apoptosis and is regulated by p53/TP53.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 16.1 kDa. The protein migrates as 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_064671.2 | |
| 100 μg | |
| Asn 53 - Lys 180 | |
| TNFRSF10B,TRAILR2,TRAIL-R2,CD262,DR5,KILLER,TRICK2,ZTNFR9,TRICKB | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 16.1 kDa | |
| Mouse TRAIL R2, His Tag (TR2-M52H5) is expressed from human 293 cells (HEK293). It contains AA Asn 53 - Lys 180 (Accession # Q9QZM4-1). | |
| -20°C | |
| TRAIL R2 | |
| Mouse | |
| PBS, pH7.4 | |
| HEK293 | |
| Bio-Markers and CD Antigens |