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ACROBiosystems Cynomolgus B7-H2 / ICOSLG Protein, His Tag
Marke: ACROBiosystems B72-C52Hb-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
ICOS ligand (ICOSLG) is also known as B7 homolog 2 (B7-H2), B7-related protein 1 (B7RP-1) and CD antigen CD275, which belongs to the immunoglobulin superfamily and BTN/MOG family. ICOSLG contains one Ig-like C2-type (immunoglobulin-like) domain and one Ig-like V-type (immunoglobulin-like) domain. Isoform 1 is widely expressed, while isoform 2 is detected only in lymph nodes, leukocytes and spleen. B7-H2 is ligand for the T-cell-specific cell surface receptor ICOS. B7-H2 acts as a costimulatory signal for T-cell proliferation and cytokine secretion and induces also B-cell proliferation and differentiation into plasma cells. B7-H2 could play an important role in mediating local tissue responses to inflammatory conditions, as well as in modulating the secondary immune response by co-stimulating memory T-cell function.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 28.5 kDa. The protein migrates as 40-55 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| XP_005548617.1 | |
| 100 μg | |
| Asp 19 - Thr 256 | |
| ICOSLG,B7-H2,B7H2,B7RP-1,B7RP1,CD275,GL50,ICOS-L,ICOSL,LICOS,ICOS ligand | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 28.5 kDa | |
| Cynomolgus B7-H2, His Tag (B72-C52Hb) is expressed from human 293 cells (HEK293). It contains AA Asp 19 - Thr 256 (Accession # XP_005548617.1). | |
| -20°C | |
| B7-H2 | |
| Cynomolgus Monkey | |
| PBS, pH7.4 | |
| HEK293 | |
| Immune Checkpoint Proteins |