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ACROBiosystems Human GITR Ligand / TNFSF18 Protein, His Tag
Marke: ACROBiosystems GIL-H5249-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 20.5 kDa. The protein migrates as 23 kDa and 26 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| 20.5 kDa | |
| Human GITR Ligand, His Tag (GIL-H5249) is expressed from human 293 cells (HEK293). It contains AA Gln 50 - Ser 177 (Accession # AAH69319.1). | |
| -20°C | |
| GITR Ligand | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Immune Checkpoint Proteins |
| 100 μg | |
| Gln 50 - Ser 177 | |
| TNFSF18,AITRL,TL6,hGITRL,GITR Ligand | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |