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ACROBiosystems Human IL-13 Protein, His Tag
Marke: ACROBiosystems IL3-H52H4-50ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Interleukin 13 (IL13) is also known as ALRH, BHR1and P600, is a single-chain glycosylated polypeptide, and is a cytokine critical in regulating inflammatory and immune responses. IL13 is secreted by many cell types, but especially by T helper type 2 (Th2) cells. IL-13 induces its effects through a multi-subunit receptor that includes the alpha chain of the IL-4 receptor (IL-4Rα) and at least one of two known IL-13-specific binding chains. The functions of IL-13 overlap considerably with those of IL-4, especially with regard to changes induced on hematopoietic cells, but these effects are probably less important given the more potent role of IL-4. IL-13 induces matrix metalloproteinases (MMPs) as part of a mechanism that protects against excessive allergic inflammation that predisposes to asphyxiation. IL-13 induces many features of allergic lung disease, including airway hyperresponsiveness, goblet cell metaplasia and mucus hypersecretion, which all contribute to airway obstruction.
This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 14.2 kDa. The protein migrates as 15 kDa and 25-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_002179.2 | |
| 50 μg | |
| Gly 21 - Asn 132 | |
| IL13,ALRH,BHR1,MGC116786,MGC116788,MGC116789,P600,Interleukin-13 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 14.2 kDa | |
| Human IL-13, His Tag (IL3-H52H4) is expressed from human 293 cells (HEK293). It contains AA Gly 21 - Asn 132 (Accession # AAK53823.1). | |
| -20°C | |
| IL-13 | |
| Human | |
| PBS, pH7.4 | |
| HEK293 | |
| Cytokines and Growth Factors |