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ACROBiosystems Human CBLB / RNF56 Protein, His Tag
Marke: ACROBiosystems CBB-H5148-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Casitas B-lineage lymphoma proto-oncogene b (CBLB) is also known as RNF56. E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B-cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. Expressed in placenta, heart, lung, kidney, spleen, ovary and testis, as well as fetal brain and liver and hematopoietic cell lines, but not in adult brain, liver, pancreas, salivary gland, or skeletal muscle.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 47.0 kDa. The protein migrates as 46 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_733762.2 | |
| 100 μg | |
| Ala 39 - Phe 426 | |
| CBL-B,CBLB,RNF56 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 47.0 kDa | |
| Human CBLB, His Tag (CBB-H5148) is expressed from E.coli cells. It contains AA Ala 39 - Phe 426 (Accession # Q13191-1). | |
| -20°C | |
| CBLB | |
| Human | |
| 40 mM HEPES, 120 mM NaCl, pH7.5 | |
| E.coli | |
| Enzymes |