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ACROBiosystems Human PLAU / uPA Protein, His Tag (activated by trypsin) (active enzyme)
Marke: ACROBiosystems PLU-H5228-1mg
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Urokinase - type plasminogen activator is also known as PLAU and UPA, a serine protease with an extremely limited substrate specificity, cleaving the sequence Cys – Pro – Gly - Arg560 - Val561 – Val – Gly – Gly – Cys in plasminogen to form plasmin. uPA is a potent marker of invasion and metastasis in a variety of human cancers associated with breast, stomach, colon, bladder, ovary, brain and endometrium.uPA and its receptor (uPAR) have been implicated in a broad spectrum of pathophysiological processes, including fibrinolysis, proteolysis, inflammation, atherogenesis and plaque destabilization, all of which are involved in the pathogenesis of MI (myocardial infarction).
This protein carries a polyhistidine tag at the C-terminus. The active form of Human PLAU is a disulfide-linked heterodimer composed of long chain A (Ser 21 - Phe 177) and chain B (Ile 179 - Leu 431) with calculated MW of 17.8 kDa and 29.2 kDa. The longSpezifikation
| NP_002649.1 | |
| 1 mg | |
| Ser 21 - Leu 431 | |
| Urokinase,PLAU,ATF,UPA,URK,u-PA,BDPLT5,QPD | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by SDS-PAGE |
| 15.3 kDa, 17.8 kDa and 29.2 kDa | |
| Human PLAU, His Tag (activated by trypsin) (PLU-H5228) is expressed from human 293 cells (HEK293). It contains AA Ser 21 - Leu 431 (Accession # P00749-1). | |
| -20°C | |
| PLAU | |
| Human | |
| 25 mM HEPES, 150 mM NaCl, pH7.5 | |
| HEK293 | |
| Enzymes |