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ACROBiosystems Human Complement C5 (w917s) Protein, His Tag

Marke:  ACROBiosystems CO5-H52H7-100ug

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16467429

  • 353.08 € / 100 Mikrogramm

Voraussichtliches Versanddatum: 19-10-2021

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Beschreibung

Beschreibung

Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. C5 precursor is first processed by the removal of 4 basic residues, forming two chains, beta and alpha, linked by a disulfide bond. C5 convertase activates C5 by cleaving the alpha chain, releasing C5a anaphylatoxin and generating C5b (beta chain + alpha' chain). Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. The C5a anaphylatoxin interacts with C5AR1 and tick complement inhibitor. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation.

This protein carries a polyhistidine tag at the C-terminus. The mature form of Complement C5 is a disulfide-linked heterodimer composed of proteolytically cleaved α and β chain. Each α and β chain has a calculated MW of 73.9 kDa (β chain) and 114.3 kDa (α
Spezifikation

Spezifikation

NP_001726.2
HEK293
Human
73.9 kDa (β chain) and 114.3 kDa (α chain)
100 µg
Gln 19 - Cys 1676
Complement C5,C5,CPAMD4
Unconjugated
PBS, pH7.4
Less than 1.0 EU / µg by the LAL method.
Cytokines and Growth Factors
Powder
>95% as determined by SDS-PAGE
Human Complement C5 (w917s), His Tag (CO5-H52H7) is expressed from human 293 cells (HEK293). It contains AA Gln 19 - Cys 1676 (Accession # P01031-1 (W917S)).
-20°C
Complement C5
His Tag
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Sicherheitsdatenblatt (SDS)
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