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ACROBiosystems Human GDF-15 / MIC-1 Protein, His Tag
Marke: ACROBiosystems GD5-H5149-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1). Expression of MIC-1 mRNA in monocytoid cells is up-regulated by a variety of stimuli associated with activation, including interleukin 1β, tumor necrosis factor α (TNF-α), interleukin 2, and macrophage colony-stimulating factor but not interferon γ, or lipopolysaccharide (LPS). It is highly expressed in cardiomyocytes, adipocytes, macrophages, endothelial cells, and vascular smooth muscle cells in normal and pathological condition. GDF-15 increases during tissue injury and inflammatory states and is associated with cardiometabolic risk. Increased GDF-15 levels are associated with cardiovascular diseases such as hypertrophy, heart failure, atherosclerosis, endothelial dysfunction, obesity, insulin resistance, diabetes, and chronic kidney diseases in diabetes. Increased GDF-15 level is linked with the progression and prognosis of the disease condition.
This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 14.2 kDa. the protein migrates as 16-17 kDa under reducing (R) condition, and 27 kDa under non-reducing (NR) condition (SDS-PAGE).Spezifikation
| NP_004855.2 | |
| 100 μg | |
| Ala 197 - Ile 308 | |
| GDF15,GDF-15,MIC-1,MIC1,NAG-1,PDF,PLAB,PTGFB,NRG-1 | |
| Unconjugated | |
| His Tag | |
| Less than 1.0 EU / μg by the LAL method. | |
| Powder | |
| >90% as determined by reduced SDS-PAGE |
| 14.2 kDa | |
| Human GDF-15, His Tag (GD5-H5149) is expressed from E.coli cells. It contains AA Ala 197 - Ile 308 (Accession # Q99988-1). | |
| -20°C | |
| GDF-15 | |
| Human | |
| 60% ACN, 0.085% TFA | |
| E.coli | |
| Bio-Markers and CD Antigens |