Learn More
ACROBiosystems Biotinylated Human LOXL2 Protein, His, Avitag™
Biotinylated Protein
Marke: ACROBiosystems LO2-H82E3-200ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
Lysyl oxidase homolog 2 is also known as LOXL2, Lysyl oxidase-like protein 2, which is expressed in many tissues, highest expression in reproductive tissues, placenta, uterus and prostate, Up-regulated in a number of cancers cells and tissues. LOXL2 mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. LOXL2 acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. LOXL2 acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag. The protein has a calculated MW of 87.8 kDa.Spezifikation
87.8 kDa | |
Biotinylated Human LOXL2, His,Avitag (LO2-H82E3) is expressed from human 293 cells (HEK293). It contains AA Gln 26 - Gln 774 (Accession # Q9Y4K0-1). | |
-20°C | |
LOXL2 | |
Human | |
HEK293 | |
MABSol™ Biotin Labeled Proteins |
200 μg | |
Gln 26 - Gln 774 | |
Lysyl oxidase homolog 2,LOXL2 | |
Precision Avi | |
His Tag and Avi Tag | |
Powder | |
PBS, pH7.4 |