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ACROBiosystems Human Glypican 2 / GPC2 Protein, Fc Tag

Marke:  ACROBiosystems GP2-H5255-100ug

Weitere Details : Netto-Gewicht : 0.00010kg

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Artikelnummer. 16487589

  • 419.88 € / 100 Mikrogramm
Verfügbar ab: 09-04-2024
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Beschreibung

Beschreibung

Glypican 2 (GPC2), also known cerebroglycan, is a glycophosphatidylinositol-linked integral membrane heparan sulfate proteoglycan found in the developing nervous system. Cerebroglycan participates in cell adhesion and is thought to regulate the growth and guidance of axons. Cerebroglycan has especially high affinity for laminin-1. GPC2 silencing inactivates Wnt/β-catenin signaling and reduces the expression of N-Myc, an oncogenic driver of neuroblastoma tumorigenesis. Immunotoxins and chimeric antigen receptor (CAR) T cells targeting GPC2 inhibit neuroblastoma growth in mouse models. A GPC3 specific antibody drug conjugate (ADC) can also inhibit neuroblastoma cell proliferation.

This protein carries a human IgG1 Fc tag at the C-terminus. This protein contains a furin cleavage site, 355-RNRR-358, and will be processed into N and C-terminal fragment with calculated MW of 37.3 kDa and 47.3 kDa respectively. The N and C‐terminal frag
Spezifikation

Spezifikation

NP_689955.1
100 μg
Ser 24 - Ser 553
Glypican 2,GPC2
Unconjugated
Fc Tag
Less than 1.0 EU / μg by the LAL method.
Powder
>95% as determined by SDS-PAGE
37.3 kDa and 47.3 kDa
Human Glypican 2, Fc Tag (GP2-H5255) is expressed from human 293 cells (HEK293). It contains AA Ser 24 - Ser 553 (Accession # Q8N158-1).
-20°C
Glypican 2
Human
Tris with Glycine, Arginine and NaCl, pH7.5
HEK293
Bio-Markers and CD Antigens
Produktvorschläge

Produktvorschläge

Videos
Sicherheitsdatenblatt (SDS)
Dokumentation

Dokumentation

Zertifikate
Sonderangebote

Sonderangebote