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ACROBiosystems Human Siglec-2 / CD22 Protein, Llama IgG2b Fc Tag, low endotoxin
low endotoxin
Marke: ACROBiosystems SI2-H525a-100ug
Weitere Details : Netto-Gewicht : 0.00010kg
Beschreibung
B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.
This protein carries a llama IgG2b Fc tag at the C-terminus. The protein has a calculated MW of 103.0 kDa. The protein migrates as 120-140 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.Spezifikation
| NP_001762.2 | |
| 100 μg | |
| Asp 20 - Arg 687 | |
| CD22,SIGLEC2,BL-CAM,SIGLEC-2,Siglec2,SIGLEC2FLJ22814 | |
| Unconjugated | |
| Llama IgG Fc Tag | |
| Less than 0.01 EU / μg by the LAL method. | |
| Powder | |
| >95% as determined by SDS-PAGE |
| 103.0 kDa | |
| Human Siglec-2, Llama IgG2b Fc Tag, low endotoxin (SI2-H525a) is expressed from human 293 cells (HEK293). It contains AA Asp 20 - Arg 687 (Accession # P20273-1). | |
| -20°C | |
| Siglec-2 | |
| Human | |
| Tris with Glycine, Arginine and NaCl, pH7.5 | |
| HEK293 | |
| Bio-Markers and CD Antigens |